Analytical Data
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基因名
RAB27B
- Application
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别名
C25KG
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O00194
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表达区间
2-218aa
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分子量
40.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RAB27B is a member of the RAB GTPase family, which plays a crucial role in intracellular vesicle trafficking and exocytosis. It is particularly involved in the regulation of secretory pathways in various cell types, including melanocytes, platelets, and immune cells. The study of RAB27B has gained prominence due to its significant implications in various physiological and pathological processes, including pigmentation, immune response, and cancer metastasis. Dysregulation of RAB27B has been linked to several diseases, such as Griscelli syndrome, which is characterized by immunological defects and hypopigmentation. Furthermore, RAB27B is involved in the secretion of cytotoxic granules in T cells and natural killer (NK) cells, making it a potential target for immunotherapy. The recombinant expression of RAB27B in different host systems allows researchers to investigate its functional roles, explore its interaction with effector proteins, and study its involvement in cellular processes. Understanding the molecular mechanisms of RAB27B can provide insights into its contributions to disease, paving the way for novel therapeutic strategies that could modulate its activity for clinical benefits. As such, RAB27B has become a focal point in cell biology and therapeutic research aimed at addressing conditions linked to its dysfunction.
