Analytical Data
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基因名
FITC-Labeled CD72
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简介
CD72 Protein plays a key role in orchestrating B-cell proliferation and differentiation, forming homodimers with disulfide linkages and interacting with CD5. It engages in tyrosine phosphorylation interactions with PTPN6/SHP-1, indicating its modulation of cellular responses through phosphorylation-based regulatory mechanisms. This underscores the multifaceted role of CD72 in the dynamic landscape of B-cell function and signaling. FITC-Labeled CD72 Protein, Human (HEK293, Fc) is the recombinant human-derived FITC-Labeled CD72 protein, expressed by HEK293 , with Fc labeled tag.
- Application
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别名
CD72; Lyb-2; Lyb2
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种属
Human
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表达系统
HEK293
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标签
Fc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P21854
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表达区间
R117-D359
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蛋白长度
Extracellular Domain
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分子量
60-65 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD72 is a type II transmembrane glycoprotein that plays a vital role in regulating B cell function and is implicated in various immune responses. As a member of the Fc receptor family, CD72 interacts with its ligand, CD100, influencing B cell activation, proliferation, and differentiation. The study of CD72 is particularly relevant in the context of autoimmune diseases and lymphoproliferative disorders, where its expression and activity are often dysregulated. The development of FITC-labeled CD72 recombinant protein allows for enhanced visualization and characterization of CD72 interactions and its biological functions in vitro and in vivo. By employing fluorescein isothiocyanate (FITC) as a fluorescent tag, researchers can track the protein's localization, quantify its binding with ligands, and analyze its role in signaling pathways. This approach not only aids in dissecting the molecular mechanisms underlying CD72's function but also provides insights for potential therapeutic strategies. Understanding CD72's interactions and signaling could lead to novel approaches in treating diseases where B cell function is compromised. Thus, the development and utilization of FITC-labeled CD72 recombinant protein represent a significant advancement in the field of immunology, providing a powerful tool for probing the complexities of B cell biology and the immune system as a whole.
