Analytical Data
-
Gene name
LY6G6D
-
简介
LY6G6D Protein is a leukocyte antigen-6 (LY6) gene cluster located in the Major Histocompatibility complex (MHC) Class III region of chromosome 6. LY6G6D Protein is involved in the JAK-STAT5 and RAS-MEK-ERK signaling pathways, and is a selective expression of colorectal cancer antigen. Therapeutic T-cell responses can be targeted through T-cell adaptors. LY6G6D Protein, Human (P.pastoris, His) is the recombinant human-derived LY6G6D protein, expressed by P. pastoris , with N-6*His labeled tag.
- Application
-
Alternative Names
LY66D_HUMAN; Ly6g6d; Lymphocyte antigen 6 complex locus protein G6d; Megakaryocyte-enhanced gene transcript 1 protein; Protein Ly6-D
-
Species
Human
-
Source
P. pastoris
-
Tag
N-6*His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
O95868
-
Expression Region
N20-S104
-
Protein Length
Full Length of Mature Protein
-
Molecular Weight
11 & 22 kDa in SDS-PAGE may be due to homodimer
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
LY6G6D, a member of the Ly6 family of proteins, plays a crucial role in various biological processes, particularly in the immune system. Its expression is predominantly observed in hematopoietic tissues and immune cells, suggesting its involvement in cell signaling and communication within the immune response. Research has shown that LY6G6D may contribute to the regulation of T cell activation and differentiation, potentially impacting autoimmunity and tumor immunity. As a result, understanding the mechanisms by which LY6G6D influences immune functions can provide valuable insights for therapeutic strategies targeting immune-related diseases. Recent studies have employed recombinant protein techniques to produce LY6G6D for functional assays and structural investigations, which can facilitate delineating its interactions with other cellular molecules. This advance in recombinant technology underscores the importance of LY6G6D as a target for further exploration in immunology, potentially leading to novel approaches in treating conditions such as cancer and autoimmune disorders. Overall, the study of LY6G6D and its recombinant protein forms is significant for elucidating its biological roles and therapeutic potential in enhancing immune responses.
