Analytical Data
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Gene name
MAGP-2/MFAP5
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简介
MAGP-2/MFAP5 protein may affect hematopoiesis and participate in blood cell formation. In the cardiovascular system, it regulates growth factors, maintains the integrity of large blood vessels through cell signaling, and contributes to the structural organization of elastin-associated microfibrils. MAGP-2/MFAP5 Protein, Human (His-SUMO) is the recombinant human-derived MAGP-2/MFAP5 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.
- Application
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Alternative Names
MAGP2; MAGP-2; MAGP2MFAP-5; MFAP5; Microfibril-associated glycoprotein 2; microfibrillar associated protein 5; microfibrillar-associated protein 5; MP25; MP25microfibril-associated glycoprotein-2; Q13361
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Species
Human
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Source
E. coli
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Tag
N-SUMO;N-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13361-1
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Expression Region
I22-L173
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Protein Length
Full Length of Isoform-1 Mature Protein
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Molecular Weight
36 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MAGP-2 (Microfibril-Associated Glycoprotein 2) and MFAP5 (Microfibril-Associated Protein 5) are important components of the extracellular matrix, playing critical roles in the structural integrity and function of connective tissues. Both proteins are associated with microfibrils, which are essential for elastic fiber formation and tissue elasticity. Research has shown that MAGP-2 participates in various biological processes, including cell adhesion, migration, and proliferation, influencing numerous physiological and pathological conditions, such as cardiovascular diseases and fibrosis. Meanwhile, MFAP5 is known to interact with other matrix proteins and may be involved in the regulation of cell behavior and tissue remodeling. The exploration of MAGP-2 and MFAP5 in the context of connective tissue disorders has prompted scientists to investigate recombinant forms of these proteins to better understand their functions, interactions, and potential therapeutic applications. Recombinant MAGP-2 and MFAP5 proteins can be utilized in biochemical assays, structural studies, and even in tissue engineering, offering insights into their roles in health and disease. By studying these proteins in detail, researchers aim to uncover novel mechanisms underlying extracellular matrix dynamics, paving the way for the development of targeted interventions for various fibrotic and degenerative conditions.
