Recombinant Human GlyT1 Protein (HEK293)，His & GFP

SLC12A1, a member of the solute carrier family, encodes a key transporter responsible for the reabsorption of sodium and chloride in the kidneys, playing a crucial role in maintaining electrolyte balance and blood pressure homeostasis. Mutations in the SLC12A1 gene have been linked to genetic forms of hypertension, such as Gitelman syndrome, characterized by hypokalemic metabolic alkalosis, hypomagnesemia, and renal wasting of electrolytes. Research on recombinant SLC12A1 protein is pivotal for understanding its functional mechanisms and the pathophysiology of related disorders. The expression of SLC12A1 in heterologous systems allows for detailed biochemical and pharmacological studies, offering insights into the transport processes and interactions with pharmacological agents. Furthermore, such studies may facilitate the development of targeted therapies for diseases associated with SLC12A1 dysfunction. As the normotensive and hypertensive states are influenced by the function of renal transporters like SLC12A1, understanding its structure-function relationship through the analysis of recombinant proteins is essential. Research in this area additionally contributes to the broader field of membrane transport biology, potentially revealing novel therapeutic targets for managing hypertension and electrolyte imbalances.