Analytical Data
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基因名
NFE2L2
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简介
The NFE2L2 protein is a key transcription factor that activates cytoprotective genes in response to oxidative stress by binding to the antioxidant response element (ARE). Normally, the BCR(KEAP1) complex degrades NFE2L2 in the cytoplasm.
- Application
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别名
Nuclear factor erythroid 2-related factor 2; NFE2-related factor 2; NF-E2-related factor 2; Nuclear factor, erythroid derived 2, like 2; Nrf2
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种属
Mouse
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表达系统
E. coli
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标签
N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q60795
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表达区间
M1-N597
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蛋白长度
Full Length
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分子量
Observed band size: 100 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NFE2L2, also known as NRF2 (nuclear factor erythroid 2-related factor 2), is a transcription factor that plays a pivotal role in cellular responses to oxidative stress and electrophilic attack. It is a key regulator of the antioxidant response, orchestrating the expression of a variety of cytoprotective genes that help mitigate damage caused by reactive oxygen species (ROS) and various environmental toxins. The study of NFE2L2 is particularly relevant in the context of various diseases, including cancer, neurodegenerative disorders, and inflammation, where oxidative stress is a contributing factor. Research has shown that dysregulation of NFE2L2 can lead to decreased antioxidant defenses, promoting disease progression. Recombinant NFE2L2 proteins have gained significant interest in the field of biomedical research, as they provide a valuable tool for investigating the molecular mechanisms underlying the antioxidant response and for screening compounds that can activate or inhibit NFE2L2 activity. Furthermore, understanding how NFE2L2 functions at the molecular level can aid in the development of novel therapeutic strategies aimed at enhancing cellular resilience against oxidative damage. Its potential as a pharmacological target highlights the importance of ongoing research into NFE2L2 and its associated pathways, making it a focal point for studies aiming to improve human health and combat oxidative stress-related diseases.
