Analytical Data
-
基因名
PARP1
- Application
-
别名
PARP1; ADPRT; ADPRT1; PPOL; pADPRT-1; ADP-ribosyltransferase diphtheria toxin-like 1; NAD(+) ADP-ribosyltransferase 1
-
种属
Mouse
-
表达系统
E. coli
-
标签
N-His
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
P11103
-
表达区间
Lys661~Pro881
-
分子量
29kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PARP1 (Poly(ADP-ribose) polymerase 1) is an enzyme that plays a critical role in cellular processes, including DNA repair, genomic stability, and programmed cell death. Research into PARP1 has gained significant momentum due to its involvement in various diseases, particularly cancer. Dysregulation of PARP1 activity is linked to tumorigenesis, making it a promising target for therapeutic intervention. Inhibitors of PARP1 have emerged as a novel class of anti-cancer drugs, especially in treating BRCA1/2-mutated cancers, where they exploit the concept of synthetic lethality. Additionally, PARP1's role in the cellular response to oxidative stress and inflammation further emphasizes its importance in both normal physiology and disease states. Understanding the structure-function relationship of PARP1 through recombinant protein studies allows for insights into its enzymatic activity and regulatory mechanisms, facilitating the development of more effective PARP inhibitors and therapeutic strategies. The ongoing research into PARP1 and its pathways underscores its significance in cancer biology and the potential for targeted treatments that leverage its mechanisms for improved patient outcomes.
