Analytical Data
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基因名
IL-3R alpha/CD123
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简介
IL-3R alpha/CD123 protein, a receptor for IL3, is expressed on hematopoietic cells and governs their production and differentiation.Upon ligand binding, it heterodimerizes with IL3RB, activating JAK2 and PI3K.This activation leads to cell proliferation and differentiation, mediated by STAT5.IL-3R alpha interacts with IL3 and forms heterodimers with alpha and beta subunits, contributing to hematopoietic cell development.IL-3R alpha/CD123 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived IL-3R alpha/CD123 protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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别名
Interleukin-3 receptor subunit alpha; IL-3R-alpha; IL-3RA; CD123; Sut-1
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种属
Mouse
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表达系统
HEK293
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标签
C-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P26952-1
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表达区间
S17-K331
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蛋白长度
Extracellular Domain
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interleukin-3 receptor alpha (IL-3Rα), also known as CD123, is a crucial component of the IL-3 receptor complex that plays a significant role in hematopoiesis and immune regulation. This receptor is primarily expressed on hematopoietic stem cells, progenitor cells, and various immune cells, making it a critical target for understanding and treating hematological malignancies and immune disorders. The dysregulation or overexpression of IL-3Rα has been implicated in the pathogenesis of several diseases, including acute myeloid leukemia (AML) and other cancers, where it contributes to the survival and proliferation of malignant cells. The development of recombinant proteins of IL-3Rα/CD123 has opened avenues for targeted therapies, particularly in creating monoclonal antibodies or fusion proteins that can selectively bind to IL-3Rα-expressing cells. Moreover, these studies contribute to a deeper understanding of receptor signaling mechanisms and the potential for using IL-3Rα as a biomarker for disease progression. The ongoing research aims to explore the therapeutic potential of targeting IL-3Rα in combination with other treatments to improve outcomes in patients with hematological malignancies. Thus, the characterization of IL-3Rα/CD123 recombinant proteins is of paramount importance in both basic science and clinical applications, providing insights into new therapeutic strategies while enhancing our understanding of its biological functions in health and disease.
