Analytical Data
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Gene name
LRP-11
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简介
Low-density lipoprotein receptor-related protein 11 is a member of LRP family and it acts as a tumour promoter in cervical cancer. Low-density lipoprotein receptor-related protein 11 enables phosphoprotein binding activity. LRP-11 Protein, Human (HEK293, His) is the recombinant human-derived LRP-11 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
Low-density lipoprotein receptor-related protein 11; LRP-11
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Species
Human
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Source
HEK293
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Tag
C-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q86VZ4
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Expression Region
A38-G450
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AA Sequence
ALPPAAPLSELHAQLSGVEQLLEEFRRQLQQERPQEELELELRAGGGPQEDCPGPGSGGYSAMPDAIIRTKDSLAAGASFLRAPAAVRGWRQCVAACCSEPRCSVAVVELPRRPAPPAAVLGCYLFNCTARGRNVCKFALHSGYSSYSLSRAPDGAALATARASPRQEKDAPPLSKAGQDVVLHLPTDGVVLDGRESTDDHAIVQYEWALLQGDPSVDMKVPQSGTLKLSHLQEGTYTFQLTVTDTAGQRSSDNVSVTVLRAAYSTGGCLHTCSRYHFFCDDGCCIDITLACDGVQQCPDGSDEDFCQNLGLDRKMVTHTAASPALPRTTGPSEDAGGDSLVEKSQKATAPNKPPALSNTEKRNHSAFWGPESQIIPVMPDSSSSGKNRKEESYIFESKGDGGGGEHPAPETG
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Protein Length
Extracellular Domain
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Molecular Weight
The protein migrates as 55-78 kDa under reducing SDS-PAGE due to glycosylation.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
LRP-11, or Lipoprotein Receptor-related Protein 11, has garnered significant attention in recent years due to its potential roles in cellular processes and disease mechanisms. Originally identified as a member of the low-density lipoprotein receptor family, LRP-11 is implicated in various biological functions, including lipoprotein metabolism, cell signaling, and neuronal development. Its unique structural features suggest that it may play an important role in the endocytic pathway, influencing the uptake and trafficking of various ligands. Recent studies have also linked LRP-11 to pathological conditions, such as cancer progression and neurodegenerative diseases, raising questions about its functional significance in both health and disease. Furthermore, the development of recombinant LRP-11 proteins has enabled researchers to investigate its biochemical properties and interactions in detail. These studies are crucial for understanding how LRP-11 might serve as a potential biomarker or therapeutic target. Given its emerging importance, ongoing research aims to elucidate the precise mechanisms by which LRP-11 contributes to cellular homeostasis and its implications in various disease states, ultimately paving the way for novel therapeutic strategies.
