Analytical Data
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基因名
IL-20R alpha
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简介
IL-20R alpha Protein (IL20RA) is the alpha subunit of IL-20 receptor, forms functional heterodimers with different subunit protein and involves in STAT3 activation pathway[1]. The IL20RA/IL20RB dimer is a receptor for IL-19, IL-20 and IL-24, while the IL20RA/IL10RB dimer is a receptor for IL-26[3]. IL-20R alpha Protein is consists of 553 amino acids (M1-N553) with a transmembrane domain (251-271 a.a.). IL-20R alpha Protein, Human (HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag.
- Application
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别名
Interleukin-20 receptor subunit alpha; IL-20R-alpha; IL-20RA; CRF2-8; IL-20R1; ZcytoR7
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种属
Human
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UHF4-1
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表达区间
V30-K250
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氨基酸序列
VPCVSGGLPKPANITFLSINMKNVLQWTPPEGLQGVKVTYTVQYFIYGQKKWLNKSECRNINRTYCDLSAETSDYEHQYYAKVKAIWGTKCSKWAESGRFYPFLETQIGPPEVALTTDEKSISVVLTAPEKWKRNPEDLPVSMQQIYSNLKYNVSVLNTKSNRTWSQCVTNHTLVLTWLEPNTLYCVHVESFVPGPPRRAQPSEKQCARTLKDQSSEFKAK
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蛋白长度
Extracellular Domain
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分子量
35-50 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IL-20R alpha, a subunit of the interleukin-20 receptor complex, plays a crucial role in mediating the effects of various cytokines, particularly IL-20 and IL-24, which are involved in inflammatory responses and skin disorders such as psoriasis. The IL-20R alpha subunit is expressed predominantly in epithelial tissues, and its signaling pathways are implicated in keratinocyte proliferation and differentiation. Understanding the function and mechanism of IL-20R alpha is critical for developing targeted therapies for diseases characterized by abnormal inflammatory responses. The generation of recombinant IL-20R alpha protein allows researchers to study its structural properties, binding affinities, and downstream signaling pathways in a controlled environment. This research may provide insights into its role in immune modulation and assist in identifying novel therapeutic targets for treating inflammatory diseases. Given the increasing prevalence of chronic inflammatory conditions, investigating the biological functions of IL-20R alpha is of significant interest in the field of immunology and therapeutics, promising advancements in precision medicine for patients suffering from these debilitating conditions.
