Analytical Data
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基因名
EBF1
- Application
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别名
COE1; EBF
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种属
Human
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表达系统
E. coli
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标签
Strep;His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UH73-1
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表达区间
M24-H430
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蛋白长度
Partial
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EBF1 (Early B-Cell Factor 1) is a critical transcription factor involved in B-cell development and differentiation. Its role extends beyond hematopoiesis, influencing various cellular processes, including the regulation of gene expression during immune responses. Recent studies have highlighted the significance of EBF1 as a key player in the transcriptional program of B lineage cells, where it orchestrates the expression of genes necessary for B-cell maturation and function. Research has shown that EBF1 interacts with other transcription factors and co-factors, forming complexes that modulate target gene transcription, which is vital for maintaining B-cell identity. Additionally, EBF1 has been implicated in B-cell malignancies, such as acute lymphoblastic leukemia and lymphoma, marking it as an important biomarker and potential therapeutic target. The production of recombinant EBF1 protein facilitates the detailed study of its structure-function relationships, enabling researchers to dissect its mechanistic role in transcriptional regulation and cellular signaling pathways. Furthermore, understanding the phosphorylation and post-translational modifications of EBF1 can provide insights into its regulatory mechanisms in health and disease. The ongoing research on EBF1 recombinantly expressed proteins aims to elucidate these complex interactions, advancing our knowledge of B-cell biology and potential interventions in immunological disorders and cancers.












