Analytical Data
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Gene name
EBF1
- Application
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Alternative Names
COE1; EBF
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Species
Human
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Source
E. coli
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Tag
Strep;His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UH73-1
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Expression Region
M24-H430
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
EBF1 (Early B-Cell Factor 1) is a critical transcription factor involved in B-cell development and differentiation. Its role extends beyond hematopoiesis, influencing various cellular processes, including the regulation of gene expression during immune responses. Recent studies have highlighted the significance of EBF1 as a key player in the transcriptional program of B lineage cells, where it orchestrates the expression of genes necessary for B-cell maturation and function. Research has shown that EBF1 interacts with other transcription factors and co-factors, forming complexes that modulate target gene transcription, which is vital for maintaining B-cell identity. Additionally, EBF1 has been implicated in B-cell malignancies, such as acute lymphoblastic leukemia and lymphoma, marking it as an important biomarker and potential therapeutic target. The production of recombinant EBF1 protein facilitates the detailed study of its structure-function relationships, enabling researchers to dissect its mechanistic role in transcriptional regulation and cellular signaling pathways. Furthermore, understanding the phosphorylation and post-translational modifications of EBF1 can provide insights into its regulatory mechanisms in health and disease. The ongoing research on EBF1 recombinantly expressed proteins aims to elucidate these complex interactions, advancing our knowledge of B-cell biology and potential interventions in immunological disorders and cancers.
