Analytical Data
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Gene name
CLC1
- Application
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Alternative Names
CLC1
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Species
Human
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Source
HEK293
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P35523
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Expression Region
K81-L988
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CLC-1 (Chloride Channel 1) is a member of the CLC family of ion channels and transporters, playing a crucial role in maintaining cellular chloride homeostasis and electrical excitability in muscle and nerve tissues. Mutations in the CLCN1 gene, which encodes the CLC-1 protein, have been implicated in various myopathies, most notably myotonia congenital, a disorder characterized by delayed muscle relaxation following contraction. The study of CLC-1 recombinant protein is essential for understanding its structural and functional properties, as well as the molecular mechanisms underlying its role in ion transport. Research often involves various techniques, including site-directed mutagenesis, electrophysiology, and biochemical assays, to elucidate how specific amino acid changes affect ion flow and channel gating. Moreover, recombinant CLC-1 proteins serve as valuable tools for drug screening and the development of therapeutic interventions for chloride channel-related diseases. Understanding the dynamics of CLC-1 is not only significant for basic biophysics but also crucial for translational research aimed at developing strategies to ameliorate symptoms in affected patients. This field of study promises to advance our knowledge of muscle and nerve physiology and improve treatment options for myotonic disorders and other related conditions.
