Analytical Data
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基因名
IL-21R
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简介
Interleukin-21 receptor is a novel class I cytokine receptor that mediates its effects through the interaction with the common g chain (gc), making IL-21 the latest member of the family of gc cytokines, which includes IL-2, IL-4, IL-7, IL-9, IL-13, and IL-15. IL-21R Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived IL-21R protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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别名
Interleukin-21 receptor; IL-21 receptor; IL-21R; CD360; Nilr
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种属
Rhesus Macaque
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表达系统
HEK293
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标签
C-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
XP_005591578
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表达区间
C20-P236
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蛋白长度
Partial
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IL-21R (Interleukin-21 receptor) is a crucial component of the immune system, playing a significant role in regulating immune responses, particularly in T and B cell functions. Its interaction with IL-21, a cytokine primarily produced by activated CD4+ T cells, initiates a cascade of signaling pathways that influence cell proliferation, differentiation, and survival. Given its essential role in mediating various immune responses, including those associated with autoimmunity, cancer, and infectious diseases, understanding IL-21R's structure and function has gained immense importance. Researchers have focused on producing recombinant IL-21R to study its biological properties, signaling mechanisms, and potential therapeutic applications. Recombinant IL-21R can serve as a valuable tool in developing targeted therapies for diseases characterized by immune dysregulation. By elucidating its interaction with IL-21 and downstream signaling pathways, scientists aim to uncover novel strategies for modulating immune responses, which could lead to advancements in treatments for conditions like lymphoma, autoimmune disorders, and chronic infections. The exploration of IL-21R through recombinant protein technologies thus holds promise for advancing our understanding of immunology and improving therapeutic interventions.
