Analytical Data
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Gene name
IL-13R alpha 2
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简介
IL-13R alpha 2 Protein, functioning as a monomer, exhibits high-affinity binding exclusively to interleukin-13 (IL13) without interaction with interleukin-4 (IL4). This binding selectivity indicates a unique role and specificity for IL-13R alpha 2 in mediating cellular responses to IL13, emphasizing its importance in IL13-associated cellular processes. IL-13R alpha 2 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived IL-13R alpha 2 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
Interleukin-13 receptor subunit alpha-2; IL-13R-alpha-2; IL-13RA2; CD213a2; IL13RA2; IL13R
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Species
Human
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Source
HEK293
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14627
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Expression Region
D27-L342
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Protein Length
Extracellular Domain
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interleukin-13 receptor alpha 2 (IL-13Rα2) is a protein that plays a crucial role in cytokine signaling, specifically in the immune response mediated by interleukin-13 (IL-13), a key player in allergic reactions and asthma. Elevated levels of IL-13Rα2 have been associated with various pathological conditions, including cancer, where it can contribute to tumor progression and immune evasion. The unique binding affinity of IL-13Rα2 for IL-13, in contrast to its other receptor complexes, makes it a potential target for therapeutic interventions. Research has increasingly focused on the re-engineering of IL-13Rα2 into recombinant proteins for various applications, including targeted drug delivery systems and immunotherapy. By harnessing the specificity of IL-13Rα2, scientists aim to develop innovative treatments that selectively destroy tumor cells while minimizing damage to healthy tissues. Understanding the structural and functional properties of IL-13Rα2, along with its interactions in various disease states, is paramount for advancing treatment strategies and potentially improving outcomes for patients suffering from IL-13-associated diseases. As a result, IL-13Rα2 recombinant proteins are gaining attention in both basic research and clinical settings, paving the way for novel therapeutic avenues.
