Analytical Data
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Gene name
CALB1
- Application
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Alternative Names
(Calbindin D28)(D-28K)(Vitamin D-dependent calcium-binding protein, avian-type)
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Species
Human
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Source
Yeast
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Tag
C- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P05937
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Expression Region
2-261aa
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Molecular Weight
30.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CALB1, or Calbindin-D28k, is a high-affinity calcium-binding protein predominantly expressed in various tissues, including the brain, where it plays a crucial role in calcium homeostasis and signaling processes. Research into CALB1 has garnered significant attention due to its involvement in numerous physiological functions, such as neurotransmitter release and neuronal protection against excitotoxicity. Changes in CALB1 expression levels have been associated with several neurological disorders, including Alzheimer's disease, schizophrenia, and epilepsy, highlighting its potential as a biomarker for disease progression. Additionally, CALB1's unique structural properties make it an ideal candidate for recombinant protein studies aimed at understanding calcium binding mechanisms and developing therapeutic strategies that target calcium dysregulation. Recombinant CALB1 proteins can be produced using techniques like bacterial expression systems, allowing for detailed biochemical characterization and functional assays. These studies are crucial for elucidating the role of CALB1 in health and disease, with implications for developing drugs that can modulate its activity or mimic its function, ultimately contributing to the advancement of treatments for related neurological conditions.
