Analytical Data
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Gene name
GASP-1/WFIKKN2
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简介
GASP-1/WFIKKN2, a multifaceted protease inhibitor with distinct domains, potentially inhibits serine proteases and metalloproteases. Its intriguing role involves inhibiting mature myostatin activity, leaving activin unaffected. GASP-1/WFIKKN2's engagement with both mature and propeptide forms of myostatin/MSTN adds complexity to the regulatory landscape of protease activities in biological systems. GASP-1/WFIKKN2 Protein, Human (HEK293, His) is the recombinant human-derived GASP-1/WFIKKN2 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
Growth and differentiation factor-associated serum protein 1; GASP-1; WFIKKN2; WFIKKNRP
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Species
Human
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Source
HEK293
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Tag
C-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q8TEU8
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Expression Region
L35-H576
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AA Sequence
LPPIRYSHAGICPNDMNPNLWVDAQSTCRRECETDQECETYEKCCPNVCGTKSCVAARYMDVKGKKGPVGMPKEATCDHFMCLQQGSECDIWDGQPVCKCKDRCEKEPSFTCASDGLTYYNRCYMDAEACSKGITLAVVTCRYHFTWPNTSPPPPETTMHPTTASPETPELDMAAPALLNNPVHQSVTMGETVSFLCDVVGRPRPEITWEKQLEDRENVVMRPNHVRGNVVVTNIAQLVIYNAQLQDAGIYTCTARNVAGVLRADFPLSVVRGHQAAATSESSPNGTAFPAAECLKPPDSEDCGEEQTRWHFDAQANNCLTFTFGHCHRNLNHFETYEACMLACMSGPLAACSLPALQGPCKAYAPRWAYNSQTGQCQSFVYGGCEGNGNNFESREACEESCPFPRGNQRCRACKPRQKLVTSFCRSDFVILGRVSELTEEPDSGRALVTVDEVLKDEKMGLKFLGQEPLEVTLLHVDWACPCPNVTVSEMPLIIMGEVDGGMAMLRPDSFVGASSARRVRKLREVMHKKTCDVLKEFLGLH
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Protein Length
Full Length of Mature Protein
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Molecular Weight
70-75 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GASP-1, also known as WFIKKN2, is a member of the WAP-type four-disulfide core (WFIKK) protein family, which plays a significant role in various physiological processes, including cell growth, differentiation, and apoptosis. This protein is characterized by its unique structural features, such as the presence of multiple WAP domains, which are known for their ability to bind and regulate growth factors and other signaling molecules. The study of GASP-1/WFIKKN2 has gained attention due to its potential involvement in cancer biology, where it may act as a tumor suppressor by modulating signaling pathways that govern cell proliferation and survival. Furthermore, dysregulation of GASP-1/WFIKKN2 expression has been implicated in various pathological conditions, including obesity and metabolic disorders. Understanding the molecular mechanisms underlying the function of GASP-1/WFIKKN2 could provide valuable insights into its role in health and disease, paving the way for novel therapeutic strategies. The recombinant protein has been generated for use in biochemical assays and structural studies, which are essential for elucidating its specific interactions and physiological functions. Researchers aim to delineate its role in cellular signaling cascades and its potential as a biomarker or therapeutic target in diseases where GASP-1/WFIKKN2 is aberrantly expressed.
