Analytical Data
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基因名
OGN/Osteoglycin
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简介
OGN/osteoglycinin cooperates with TGF-β-1 or TGF-β-2 to play a crucial role in bone formation. Its synergistic interaction with these growth factors emphasizes its importance in regulating bone homeostasis and development. OGN/Osteoglycin Protein, Human (HEK293, His) is the recombinant human-derived OGN/Osteoglycin protein, expressed by HEK293 , with C-His labeled tag.
- Application
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别名
Mimecan; Osteoglycin; OIF; OGN; SLRR3A
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种属
Human
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表达系统
HEK293
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标签
C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P20774
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表达区间
P21-F298
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氨基酸序列
PPTQQDSRIIYDYGTDNFEESIFSQDYEDKYLDGKNIKEKETVIIPNEKSLQLQKDEAITPLPPKKENDEMPTCLLCVCLSGSVYCEEVDIDAVPPLPKESAYLYARFNKIKKLTAKDFADIPNLRRLDFTGNLIEDIEDGTFSKLSLLEELSLAENQLLKLPVLPPKLTLFNAKYNKIKSRGIKANAFKKLNNLTFLYLDHNALESVPLNLPESLRVIHLQFNNIASITDDTFCKANDTSYIRDRIEEIRLEGNPIVLGKHPNSFICLKRLPIGSYF
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蛋白长度
Full Length of Mature Protein
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分子量
45-60 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Osteoglycin (OGN) is a small leucine-rich proteoglycan that plays a crucial role in bone and cartilage development, tissue repair, and cell signaling. Emerging research highlights its significance in the extracellular matrix, influencing cellular activities like proliferation and differentiation. Alterations in OGN expression have been linked to various musculoskeletal disorders, including osteoarthritis and osteoporosis, making it a potential biomarker and therapeutic target. The study of recombinant OGN protein offers insights into its precise biological functions and mechanisms. Through recombinant technology, scientists can produce and manipulate OGN for in-depth functional analyses, paving the way for novel treatments aimed at restoring tissue integrity and function in degenerative diseases. Ongoing investigations focus on understanding OGN's interactions within the extracellular matrix and its effects on cartilage homeostasis, which may lead to innovative therapeutic strategies. Overall, research on recombinant OGN protein not only enhances our understanding of its fundamental biological roles but also contributes to advancing regenerative medicine approaches for treating musculoskeletal disorders.
