Analytical Data
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Gene name
SUMO3
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简介
SUMO3 is a multifunctional ubiquitin-like protein that can attach to target lysines, acting as a monomer or forming lysine-linked polymers. Unlike ubiquitin, SUMO3 is not involved in protein degradation; instead, it may counteract ubiquitin degradation. SUMO3 Protein, Human (HEK293, His) is the recombinant human-derived SUMO3 protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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Alternative Names
Small ubiquitin-related modifier 3; SUMO-3; SMT3 homolog 1; SUMO-2; Ubiquitin-like protein SMT3A; Smt3A
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Species
Human
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P55854
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Expression Region
S2-G92
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Protein Length
Partial
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Molecular Weight
21.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SUMO3 (Small Ubiquitin-like Modifier 3) is a member of the SUMO (Small Ubiquitin-like Modifier) protein family, which plays a crucial role in post-translational modifications influencing various cellular processes, including protein stability, localization, and activity. The study of SUMO3 is particularly significant due to its involvement in several critical biological functions, such as cell cycle regulation, DNA repair, and stress response, which are essential in maintaining cellular homeostasis. Abnormal SUMOylation, the process by which SUMO proteins are conjugated to target proteins, has been implicated in various diseases, including cancer, neurodegenerative disorders, and inflammatory diseases. Research on SUMO3 has gained momentum in recent years as scientists aim to unravel its specific roles and mechanisms within cellular pathways. Understanding how SUMO3 interacts with other proteins and pathways can provide insights into its potential as a therapeutic target. Advances in techniques such as proteomics and structural biology have facilitated the investigation of SUMO3’s structure-function relationship and its dynamics within the SUMOylation pathway. This knowledge not only contributes to a deeper comprehension of SUMO3's biological significance but also enhances our understanding of the wider implications of SUMOylation in health and disease. Consequently, ongoing studies focus on elucidating the regulatory networks involving SUMO3, aiming to identify novel modulators or inhibitors that could be leveraged for therapeutic applications, paving the way for innovative strategies in treating SUMO-related diseases.
