Analytical Data
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Gene name
REG-3 gamma/REG3G
- Application
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Alternative Names
Pancreatitis-associated protein 3Regenerating islet-derived protein III-gamma ;Reg III-gamma
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Species
Rat
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Source
Yeast
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P42854
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Expression Region
27-174aa
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Molecular Weight
18.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
REG3G, also known as Regenerating Islet-Derived 3 Gamma, is a member of the regenerating family of proteins that plays a crucial role in the immune response, particularly within the gastrointestinal tract. This protein is primarily produced by Paneth cells in the intestines and is known for its antimicrobial properties, specifically against a wide range of pathogens, including bacteria and fungi. REG3G functions by binding to the surface of microorganisms, disrupting their membrane integrity, and thus inhibiting their growth. Recent studies have highlighted its potential involvement in various diseases, such as inflammatory bowel disease (IBD) and colorectal cancer, where it may act as both a protector and a marker of intestinal health. Furthermore, REG3G has been shown to have regulatory effects on the intestinal microbiota, suggesting that it plays a significant role in maintaining gut homeostasis. The recombinant form of REG3G (REG-3 gamma) has become an area of interest for researchers seeking to explore its therapeutic potential, not only for its antimicrobial effects but also for its possible applications in regenerative medicine, improving gut health, and modulating immune responses. Understanding the detailed mechanisms by which REG3G operates could pave the way for novel treatments targeting gastrointestinal disorders and enhancing our knowledge of host-microbe interactions in the intestine.
