Analytical Data
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基因名
Stathmin
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简介
Stathmin Protein, a widely distributed cytosolic phosphoprotein, integrates regulatory signals and destabilizes microtubules, crucial for their assembly and disassembly. It exhibits broad expression in various tissues, highlighting its versatile role in cellular processes. Stathmin Protein, Human (His) is the recombinant human-derived Stathmin protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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别名
"Stathmin; Leukemia-Associated Phosphoprotein p18; Metablastin; Oncoprotein 18; Op18; Phosphoprotein p19; pp19; Prosolin; Protein Pr22; pp17; STMN1; C1orf215; LAP18; OP18 "
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种属
Human
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表达系统
E. coli
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标签
N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P16949-1
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表达区间
A1-D149
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蛋白长度
Full Length of Isoform-1
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分子量
19 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Stathmin, also known as oncoprotein 18, is a crucial regulatory protein involved in microtubule dynamics, influencing cell division, signaling pathways, and cytoskeletal organization. Discovered in the early 1990s, it has garnered significant interest due to its role in cancer progression and metastasis, as it is often overexpressed in various malignancies. Stathmin functions primarily by sequestering tubulin dimers, thereby preventing their assembly into microtubules, which is essential for maintaining cellular architecture and proper mitotic function. The dysregulation of stathmin activity can lead to aberrant cell proliferation and resistance to apoptosis, making it a potential therapeutic target. Recent studies have focused on the structure-function relationship of stathmin and the development of stathmin-targeting compounds. Recombining stathmin offers a means to study its functional properties in detail, facilitating a better understanding of its involvement in cellular processes and disease mechanisms. Moreover, elucidating the molecular mechanisms governing stathmin’s activity can inform the design of novel cancer therapies aimed at disrupting its pro-tumorigenic effects. This research not only enhances our fundamental knowledge of cell biology but also opens avenues for targeted interventions in cancer treatment.
