Analytical Data
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Gene name
SH2D1A
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简介
SH2D1A protein regulates receptors of the SLAM family (SLAMF1, CD244, LY9, CD84, SLAMF6, and SLAMF7). SH2D1A Protein, Human (His) is the recombinant human-derived SH2D1A protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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Alternative Names
SH2 Domain-Containing Protein 1A; Duncan Disease SH2-Protein; Signaling Lymphocytic Activation Molecule-Associated Protein; SLAM-Associated Protein; T-Cell Signal Transduction Molecule SAP; SH2D1A; DSHP; SAP
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Species
Human
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Source
E. coli
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Tag
N-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O60880
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Expression Region
M1-P128
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Protein Length
Full Length
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Molecular Weight
16.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SH2D1A, also known as SRC Homology 2 Domain Containing 1A, is a crucial protein that plays a significant role in immune signaling and T cell activation. Disruptions in SH2D1A function have been linked to several immunological disorders, including X-linked lymphoproliferative disease (XLP), which manifests in severe immune deficiencies and increased susceptibility to infections and lymphoma. The study of SH2D1A recombinant proteins has gained attention in recent years due to their potential in understanding the molecular mechanisms underlying T cell signaling pathways and their implications in immune responses. Researchers are focusing on characterizing the structure and function of SH2D1A, analyzing its interactions with other signaling molecules, and elucidating its role in lymphocyte differentiation and activation. Moreover, recombinant SH2D1A can serve as a valuable tool for developing therapeutic strategies aimed at modulating immune responses in conditions characterized by hyperactivation or inadequate immune function. By exploring the dynamics of SH2D1A in vitro, scientists are hoping to uncover innovative approaches for treating immune-related diseases, thereby enhancing our understanding of immune regulation and fostering advancements in medical science.
