Analytical Data
-
基因名
IL-2Rg
-
简介
IL-2R gamma (CD132), a type I cytokine receptor expressed on leucocyte subsets, is a receptor for IL-2. IL-2R gamma forms heterodimer with IL-2R beta, and increases the affinity of IL-2R beta for IL-2[1]. IL-2R gamma plays an important role in the development, activation, proliferation, differentiation and regulation of lymphocytes and other cell types[2]. IL-2R gamma/CD132 Protein, Human (HEK293, His) is a recombinant human extracellular region of IL-2R gamma (L23-A262) with a C-Terminal 6*His tag, which is produced in HEK293 cells.
- Application
-
别名
IL-2RG; IL-2 R gamma; IL-2Rγ; IL2R γ; Cytokine receptor common subunit gamma; Interleukin-2 receptor subunit gamma; gammaC; P64; CD132 and IL2RG
-
种属
Human
-
表达系统
HEK293
-
标签
C-6*His
-
纯度
> 90% as determined by SDS-PAGE.
-
蛋白编号
P31785
-
表达区间
L23-A262
-
氨基酸序列
LNTTILTPNGNEDTTADFFLTTMPTDSLSVSTLPLPEVQCFVFNVEYMNCTWNSSSEPQPTNLTLHYWYKNSDNDKVQKCSHYLFSEEITSGCQLQKKEIHLYQTFVVQLQDPREPRRQATQMLKLQNLVIPWAPENLTLHKLSESQLELNWNNRFLNHCLEHLVQYRTDWDHSWTEQSVDYRHKFSLPSVDGQKRYTFRVRSRFNPLCGSAQHWSEWSHPIHWGSNTSKENPFLFALEA
-
蛋白长度
Extracellular Domain
-
分子量
45-85 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Interleukin-2 receptor gamma chain (IL-2Rg) plays a critical role in the immune system by serving as a shared component of several cytokine receptors, including those for interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-7 (IL-7), interleukin-9 (IL-9), interleukin-15 (IL-15), and interleukin-21 (IL-21). Its importance is underscored by the severe immunodeficiency observed in individuals with IL-2Rg mutations, known as X-linked severe combined immunodeficiency (X-SCID). The inability to produce functional T and natural killer (NK) cells leads to heightened vulnerability to infections. Research into IL-2Rg recombinant proteins has gained traction as scientists seek to better understand its structure, function, and interactions within the immune signaling pathways. Additionally, recombinant IL-2Rg is being explored for therapeutic applications, such as enhanced immunotherapy strategies for cancer and improved outcomes in gene therapy for immunodeficiencies. By providing a clearer understanding of how IL-2Rg operates, researchers aim to develop more effective treatments for a variety of immune-related disorders. The continued study of IL-2Rg recombinant proteins represents a promising frontier in immunology, with potential implications for both basic science and clinical applications.
