Analytical Data
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基因名
SLC37A4
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简介
SLC37A4 protein, an endoplasmic reticulum antiporter, transports glucose-6-phosphate into the endoplasmic reticulum lumen while moving inorganic phosphate in the opposite direction. This function is integral to glucose production through glycogenolysis and gluconeogenesis, underscoring SLC37A4's central role in regulating blood glucose levels and maintaining metabolic balance. SLC37A4 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC37A4 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
- Application
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别名
SLC37A4; Glucose-6-phosphate exchanger SLC37A4; Glucose-5-phosphate transporter; Glucose-6-phosphate translocase; Solute carrier family 37 member 4; Transformation-related gene 19 protein; TRG-19
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种属
Human
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表达系统
Baculovirus
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标签
N-MBP;C-Flag;N-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O43826
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表达区间
A2-E429
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蛋白长度
Full Length
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC37A4, a member of the solute carrier family, encodes a phosphate-dependent glucose-6-phosphate transporter that plays a crucial role in cellular metabolism. Research into SLC37A4 has gained increasing attention due to its association with various metabolic disorders, most notably Glycogen Storage Disease type I (GSDI), which results from mutations in this gene. These mutations lead to deficiencies in glycogen metabolism, causing serious complications such as hypoglycemia, lactic acidosis, and hepatomegaly. Studying the recombinant protein of SLC37A4 is essential for understanding its structure-function relationship, elucidating the mechanisms underlying the disease, and exploring potential therapeutic strategies. Expression of the recombinant protein allows for the analysis of its transport activity and substrate specificity, providing insights into its role in metabolic pathways. Furthermore, leveraging advanced techniques such as X-ray crystallography and cryo-electron microscopy can lead to a deeper understanding of the protein's conformational changes and interactions with other cellular components. As research progresses, the characterization of SLC37A4 recombinant protein stands to contribute significantly to the development of targeted treatments for GSDI and similar disorders, ultimately improving patient outcomes and enhancing our comprehension of glucose metabolism in human physiology.
