Analytical Data
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Gene name
SLC11A1
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简介
The SLC11A1 protein is a macrophage-specific antiporter that transports metal ions reversibly through proton gradients. It localizes to late endosomal lysosomal membranes and transports divalent cations into acidic compartments, affecting antibacterial activity. SLC11A1 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC11A1 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
- Application
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Alternative Names
SLC11A1; Natural resistance-associated macrophage protein 1; NRAMP 1; Solute carrier family 11 member 1
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Species
Human
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Source
Baculovirus
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Tag
N-MBP;C-Flag;N-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P49279
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Expression Region
T2-G550
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC11A1, also known as solute carrier family 11 member 1, is a gene that encodes a protein involved in the transport of divalent metal ions, particularly iron and manganese, across cellular membranes. Research has highlighted its critical role in the immune response, particularly in macrophages, where it aids in the host defense against intracellular pathogens. Mutations or polymorphisms in SLC11A1 have been associated with susceptibility to infectious diseases such as tuberculosis and certain autoimmune disorders. The interest in SLC11A1 recombinant protein arises from its potential applications in understanding disease mechanisms, developing therapeutic strategies, and designing vaccines. Recombinant SLC11A1 can be produced to investigate its functional properties, binding affinities, and interactions with other cellular components. Moreover, studying its structure can provide insights into how alterations in this protein may influence disease susceptibility. Thus, the recombinant form of SLC11A1 serves as a valuable tool for elucidating its biological functions and for exploring its role in health and disease, making it a focus of research in molecular biology and immunology.
