Analytical Data
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基因名
GEMIN6
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简介
The GEMIN6 protein is a component of the SMN complex and is critical for the assembly of small nuclear ribonucleoproteins (snRNPs), which are essential for spliceosome-mediated pre-mRNA splicing. Most spliceosomal snRNPs share a common set of Sm proteins that form a heptameric protein ring on small nuclear RNAs. GEMIN6 Protein, Human is the recombinant human-derived GEMIN6 protein, expressed by E. coli , with tag free.
- Application
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别名
GEMIN6; Gem-associated protein 6; Gemin-6; SIP2
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8WXD5
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表达区间
M1-Q167
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蛋白长度
Full Length
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GEMIN6, a member of the Gemin family of proteins, plays a crucial role in the formation and stability of spliceosomal complexes, which are essential for pre-mRNA splicing. This process is vital for gene expression regulation, as it removes non-coding sequences (introns) from pre-mRNA, enabling the generation of mature mRNA for translation into proteins. The interest in GEMIN6 has grown due to its implications in various biological processes and its potential involvement in disease mechanisms, particularly in neurodegenerative disorders like spinal muscular atrophy, where defects in RNA splicing contribute to pathogenesis. Previous research has demonstrated that GEMIN6 interacts with the SMN (Survival Motor Neuron) complex, which is critical for the assembly of small nuclear ribonucleoproteins (snRNPs), a key component of the spliceosome. Understanding the structural and functional characteristics of GEMIN6, including its interactions with other spliceosomal proteins, can provide insights into the regulation of RNA splicing and the molecular basis of related diseases. Recent advances in proteomics and structural biology techniques have enabled researchers to investigate the molecular dynamics of GEMIN6 and its role in the spliceosome more comprehensively, thereby paving the way for potential therapeutic strategies targeting RNA processing pathways. As a result, the study of GEMIN6 is not only essential for elucidating fundamental biological mechanisms but also holds promise for developing innovative treatments for splicing-related disorders.
