Analytical Data
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Gene name
BTBD9
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简介
The BTBD9 protein is invovled in regulating hippocampal synaptic plasticity and learning and memory in mice. BTBD9 is involved in formation of the limbs and cell fate determination in the developing Drosophila melanogaster. BTBD9 is also a genetic risk factor of Restless legs syndrome (RLS). BTBD9 alleviates Mn-induced oxidative stress and neurotoxicity in Caenorhabditis elegans. via regulation of insulin/insulin-like growth factor signaling pathway[1][2][3]. BTBD9 Protein, Human (sf9, His, Strep) is the recombinant human-derived BTBD9 protein, expressed by sf9 insect cells , with N-Strep, N-8*His labeled tag.
- Application
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Alternative Names
BTBD9; BTB/POZ domain-containing protein 9
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Species
Human
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Source
Baculovirus
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Tag
N-StrepⅡ;N-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96Q07
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Expression Region
S2-Q612
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BTBD9 (BTB/POZ domain-containing protein 9) is a protein implicated in various cellular processes, including gene regulation and protein-protein interactions. Dysregulation of BTBD9 has been associated with several neurodegenerative diseases and movement disorders, notably dystonia and Parkinson's disease. The interest in BTBD9 has surged due to its role as a potential biomarker and therapeutic target. Recent studies have indicated that BTBD9 may influence the aggregation of proteins linked to neurodegeneration, prompting further investigations into its structure and function. Research has focused on the recombinant expression of BTBD9 to elucidate its biological mechanisms and interactions within cellular pathways. By producing BTBD9 as a recombinant protein, scientists aim to better understand its role in disease pathogenesis and explore its potential as a target for drug development. Additionally, the study of BTBD9's structure-function relationship could reveal insights into its regulatory mechanisms, ultimately contributing to the development of novel therapeutic strategies for treating related disorders. Understanding the intricacies of BTBD9 is essential for advancing our knowledge of neurodegeneration and could lead to breakthroughs in designing effective interventions for patients afflicted with these debilitating conditions.
