Analytical Data
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基因名
ARMC5
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简介
ARMC5 protein is a vital player in fetal development, T-cell function, and adrenal gland growth homeostasis. As a negative regulator, it impacts adrenal cell survival and modulates steroidogenesis, regulating the expression of steroidogenic enzymes and cortisol production. ARMC5 Protein, Human (sf9, His, Strep) is the recombinant human-derived ARMC5 protein, expressed by sf9 insect cells , with N-Strep, N-8*His labeled tag.
- Application
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别名
ARMC5; Armadillo repeat-containing protein 5
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种属
Human
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表达系统
Baculovirus
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标签
N-StrepⅡ;N-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96C12
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表达区间
A2-A935
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蛋白长度
Partial
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ARMC5 (armadillo repeat containing 5) is a gene that has garnered significant attention in the field of cancer research, particularly in relation to adrenal tumors. Mutations in the ARMC5 gene have been linked to adrenocortical carcinoma (ACC) and primary pigmented nodular adrenocortical disease (PPNAD), which are conditions characterized by the abnormal growth of adrenal cortex cells. The study of ARMC5 recombinant protein is crucial for understanding its biological function and potential role in tumorigenesis. Recombinant ARMC5 protein can be produced in a laboratory setting, enabling researchers to investigate its structural and functional properties. This research is essential to elucidate the mechanisms through which ARMC5 mutations contribute to adrenal tumor development, potentially revealing key insights into cellular signaling pathways and regulatory mechanisms. Furthermore, understanding the interactions of ARMC5 with other proteins and its role in cellular processes may help identify novel therapeutic targets for adrenal tumors. As the incidence of adrenal cancers is relatively rare yet often aggressive, exploring the biology of ARMC5 through recombinant protein studies may pave the way for improved diagnostic and treatment strategies, enhancing patient outcomes in the long run.
