Analytical Data
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Gene name
LRRC4
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简介
LRRC4 Protein, Human (489a.a, HEK293, His) is the recombinant human-derived LRRC4 protein, expressed by HEK293, with C-His labeled tag. The total length of LRRC4 Protein, Human (489a.a, HEK293, His) is 489 a.a., with molecular weight of 90-110 kDa.
- Application
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Alternative Names
LRRC4; NGL-2; BAG; NAG14
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Species
Human
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Source
HEK293
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
AAI11562
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Expression Region
A39-K527
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Molecular Weight
90-110 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LRRC4, or Leucine-Rich Repeat Containing 4, is a protein that is gaining attention in the field of molecular biology and neuroscience due to its potential role in synaptic functioning and neurodevelopment. Initially identified in the context of the mammalian brain, LRRC4 is believed to be involved in the formation and maintenance of excitatory synapses, which are crucial for proper neuronal communication. Its function as a synaptic organizer suggests that LRRC4 could be involved in critical processes such as learning and memory. Recent studies have indicated that aberrations in LRRC4 expression may be linked to neurodevelopmental disorders and conditions such as autism spectrum disorder (ASD) and schizophrenia, thereby highlighting its importance in understanding the molecular mechanisms underlying these diseases. Furthermore, the reconstitution of LRRC4 as a recombinant protein serves as a valuable tool for investigating its physiological roles and interactions with other synaptic components. This includes elucidating its specific binding partners, post-translational modifications, and the signaling pathways it influences. Understanding the function of LRRC4 at a molecular level may ultimately provide insights into novel therapeutic strategies for treating neurodevelopmental disorders and enhancing cognitive functions. Ongoing research characterizing LRRC4 and its mechanism of action is essential for advancing our comprehension of synapse biology and addressing the challenges posed by related neurological disorders.
