Analytical Data
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Gene name
IL-15R alpha
- Application
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Alternative Names
Interleukin-15 receptor subunit alpha;Il15ra;sIL-15 receptor subunit alpha
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Species
Mouse
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Source
HEK293
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Tag
C- Fc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q60819
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Expression Region
33-205aa
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Molecular Weight
45.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interleukin-15 receptor alpha (IL-15Rα) is a critical component of the IL-15 signaling pathway, which plays a crucial role in immune system regulation, particularly in the activation and growth of natural killer (NK) cells and memory T cells. Given its significant involvement in immune responses, IL-15Rα has garnered considerable attention for its potential applications in immunotherapy and vaccine development. Researchers have been investigating the recombinant expression of IL-15Rα to enhance the understanding of its biological functions and to develop therapeutic strategies that could harness its properties. The recombinant protein facilitates studies on receptor interactions, downstream signaling pathways, and the mechanisms governing lymphocyte activation and survival. Moreover, by producing IL-15Rα as a recombinant protein, scientists aim to utilize it in clinical settings to improve immune responses against cancers and chronic infections. This has implications not only for enhancing existing treatment modalities but also for creating novel therapeutic approaches that could leverage the unique characteristics of the IL-15 pathway in the context of immune reconstitution and tumor immunology. Thus, the study of IL-15Rα recombinant protein has become an important area of research in immunology, contributing to our understanding of immune regulation and the development of innovative treatments for various diseases.
