Analytical Data
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基因名
PSAP/Prosaposin
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简介
Frizzled-7 protein is a transmembrane receptor that plays a crucial role in the Wnt signaling pathway. It is involved in cellular processes such as cell proliferation, differentiation, and migration. PSAP/Prosaposin Protein, Human (HEK293, His) is the recombinant human-derived PSAP/Prosaposin protein, expressed by HEK293 , with C-10*His labeled tag.
- Application
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别名
Proactivator polypeptide; Saposin-A; PSAP; GLBA; SAP1
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种属
Human
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表达系统
HEK293
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标签
C-10*His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
NP_002769.1
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表达区间
G17-N524
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氨基酸序列
GPVLGLKECTRGSAVWCQNVKTASDCGAVKHCLQTVWNKPTVKSLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVILDIIKGEMSRPGEVCSALNLCESLQKHLAELNHQKQLESNKIPELDMTEVVAPFMANIPLLLYPQDGPRSKPQPKDNGDVCQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMADICKNYISQYSEIAIQMMMHMQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELVEPIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGGFCEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPSAHKPLLGTEKCIWGPSYWCQNTETAAQCNAVEHCKRHVWN
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蛋白长度
Full Length of Mature Protein
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分子量
60-85 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Prosaposin (PSAP) is a multi-functional glycoprotein that plays a crucial role in lysosomal function, cell signaling, and the maintenance of tissue homeostasis. It is the precursor of four individual saposins that assist in the hydrolysis of sphingolipids, crucial for lipid metabolism and cellular communication. Mutations in the PSAP gene have been linked to several lysosomal storage diseases, underscoring its importance in human health. Recent studies have highlighted the potential therapeutic applications of PSAP and its derived peptides in neuroprotection, regenerative medicine, and inflammation regulation. The recombinant expression of PSAP and its saposin derivatives in various host systems has become a focus of research, as it allows for the study of their biological functions and the development of novel treatments. Advances in recombinant protein technology facilitate the production of active and soluble forms of PSAP, enabling researchers to explore its mechanisms of action and therapeutic potential in disease models. This research not only enhances our understanding of the protein's role in cellular processes but also opens new avenues for the development of therapies targeting lysosomal dysfunction and neurodegenerative diseases.
