Analytical Data
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Gene name
TEM8/ANTXR1
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简介
The TEM8/ANTXR1 protein is multifunctional in cell attachment and migration, interacting with extracellular matrix proteins and the actin cytoskeleton. This binding mediates cell adhesion to type 1 collagen and gelatin, promoting actin cytoskeletal reorganization and cell spreading, which is critical for cell structure and movement. TEM8/ANTXR1 Protein, Human (HEK293, Fc) is the recombinant human-derived TEM8/ANTXR1 protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Alternative Names
ANTXR1; ATR; Anthrax toxin receptor 1
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Species
Human
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H6X2-1
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Expression Region
E33-S321
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Protein Length
Extracellular Domain
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Molecular Weight
69 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The study of TEM8 (Tumor Endothelial Marker 8) and ANTXR1 (Anthrax Toxin Receptor 1) recombinant proteins has gained significant attention due to their crucial roles in tumor biology and potential therapeutic applications. TEM8 is primarily expressed in the endothelial cells of tumors and plays a pivotal role in angiogenesis, facilitating tumor growth by promoting blood vessel formation. This property makes TEM8 a promising target for anti-cancer therapies, enabling the development of targeted drug delivery systems. Similarly, ANTXR1 is known for its involvement in anthrax toxin entry into host cells and has been implicated in various physiological and pathological processes, including cell adhesion and migration. The interaction between TEM8 and ANTXR1 is believed to influence tumor microenvironment dynamics and may present novel avenues for cancer treatment. Research on the recombinant forms of these proteins aims to elucidate their structural and functional characteristics, optimize their use in targeted therapies, and explore their potential as biomarkers for cancer diagnosis and prognosis. Studying these recombinant proteins not only advances our understanding of tumor biology but also paves the way for innovative therapeutic strategies that could improve patient outcomes in oncology.
