Analytical Data
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Gene name
MDGA2
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简介
The MDGA2 protein is involved in cell-cell interactions, suggesting a role in important connections between cells. Its interaction with NLGN2 is facilitated by its Ig-like domain, specifically involving the formation of molecular associations with NLGN2 that may affect cell communication or adhesion. MDGA2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived MDGA2 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
MAM domain containing glycosylphosphatidylinositol anchor 2; MAMDC1; MDGA2
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Species
Mouse
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Source
HEK293
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P60755
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Expression Region
P26-D924
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Protein Length
Full Length of Mature Protein
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Molecular Weight
110-120 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MDGA2 (Mammalian Derailed-1 Family Protein 2) is a member of the immunoglobulin superfamily that plays a crucial role in various biological processes, including neuronal development and axon guidance. The study of MDGA2 is particularly significant due to its involvement in the regulation of cell adhesion and migration, which are essential for proper nervous system function. Aberrant expression of MDGA2 has been linked to neurodevelopmental disorders and certain cancers, highlighting its potential as a biomarker and therapeutic target. Recombinant MDGA2 proteins are synthesized for in-depth studies to elucidate their structure-function relationships, interaction with other proteins, and signaling pathways. Furthermore, these studies can provide insights into the molecular mechanisms underlying MDGA2's role in cellular processes, aided by techniques such as X-ray crystallography, NMR spectroscopy, and functional assays. Understanding MDGA2's biological functions and mechanisms may yield new avenues for therapeutic interventions in diseases where MDGA2 is implicated, thus warranting ongoing research into its recombinant forms and potential biotechnological applications.
