Analytical Data
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基因名
BIN2
- Application
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别名
rHuBIN2, His; Bridging Integrator 2; Breast Cancer-Associated Protein 1; BIN2; BRAP1
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种属
Human
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表达系统
E. coli
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标签
N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UBW5-1
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表达区间
M1-N244
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氨基酸序列
HHHHHHMAEGKAGGAAGLFAKQVQKKFSRAQEKVLQKLGKAVETKDERFEQSASNFYQQQAEGHKLYKDLKNFLSAVKVMHESSKRVSETLQEIYSSEWDGHEELKAIVWNNDLLWEDYEEKLADQAVRTMEIYVAQFSEIKERIAKRGRKLVDYDSARHHLEAVQNAKKKDEAKTAKAEEEFNKAQTVFEDLNQELLEELPILYNSRIGCYVTIFQNISNLRDVFYREMSKLNHNLYEVMSKLEKQHSN
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蛋白长度
Partial
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分子量
32 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BIN2 (BIS-NLS Interacting Protein 2) is a member of the clathrin-AP180/adaptor protein complex, playing a crucial role in clathrin-mediated endocytosis. It is primarily expressed in various tissues, including the brain, where it is involved in synaptic function and signaling pathways. Research on BIN2 has gained momentum due to its potential implications in neurodegenerative diseases and cancer. Studies indicate that BIN2 may regulate cellular processes such as membrane trafficking, cytoskeletal dynamics, and apoptosis. Alterations in BIN2 expression or function have been linked to various pathological conditions, highlighting its importance as a biomarker and therapeutic target. Recent advances in recombinant protein technology have enabled researchers to produce BIN2 in sufficient quantities for functional assays, structure-function studies, and drug discovery. Understanding the structure and interactions of BIN2 can provide insights into its role in cellular mechanisms and contribute to the development of targeted therapies. With the growing interest in its biological significance and therapeutic potential, continued investigation of BIN2-recombinant proteins holds promise for unraveling the complexities of disease pathways and identifying novel intervention strategies.
