Analytical Data
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Gene name
VSIG4
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简介
V-set and immunoglobulin domain containing 4 (Vsig4) is a membrane protein belonging to complement receptor of the immunoglobulin superfamily. Vsig4 may be a negative regulator of T-cell responses and interleukin-2 production, Vsig4 also mediates clearance of C3b opsonized pathogens by binding C3b. The expression of VSIG4 is restricted to tissue macrophages where Vsig4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism. VSIG4 Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived VSIG4 protein, expressed by HEK293 , with C-hFc, C-His labeled tag.
- Application
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Alternative Names
V-set and immunoglobulin domain-containing protein 4; Protein Z39Ig; Z39IG; CRIg
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Species
Mouse
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Source
HEK293
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Tag
C-hFc;C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
F6TUL9
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Expression Region
H20-P187
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Protein Length
Partial
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Molecular Weight
60 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
VTI1A (Vesicle Transport through Interaction with T-SNAREs 1A) is a member of the SNARE (Soluble NSF Attachment Protein Receptor) protein family, which plays a crucial role in vesicular transport and membrane fusion processes within cells. The study of VTI1A has gained significant attention due to its involvement in various physiological and pathological processes, including neurotransmitter release, organelle communication, and immune responses. Research indicates that VTI1A is essential for transporting cargo between the endoplasmic reticulum and the Golgi apparatus, linking these organelles to the plasma membrane. Disruption of VTI1A function has been associated with several diseases, such as neurodegenerative disorders and infectious diseases, where vesicular transport is impaired. Thus, understanding the structure and function of VTI1A, particularly through the development of recombinant proteins, is vital for elucidating its role in cellular processes and identifying potential therapeutic targets. Investigations involving the production and characterization of VTI1A recombinant proteins have provided insights into its mechanistic roles and interactions within the cellular landscape, paving the way for future studies on its implications in health and disease.
