Analytical Data
-
基因名
TMED9
-
简介
TMED9 is a key player in vesicle protein trafficking and plays an important role in the early secretory pathway, particularly in COPI vesicle-mediated retrograde transport. It promotes the recruitment of coat isoforms to the membrane, enhances ARFGAP2 activity, and ensures the specific retention of p24 complexes in cis-Golgi membranes, specifically affecting TMED2 and TMED10 localization. TMED9 Protein, Human (HEK293, Fc) is the recombinant human-derived TMED9 protein, expressed by HEK293 , with C-mFc labeled tag.
- Application
-
别名
Transmembrane emp24 domain-containing protein 9; GMP25; p24alpha2; p25; GP25L2
-
种属
Human
-
表达系统
HEK293
-
标签
C-mFc
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q9BVK6
-
表达区间
M1-R202
-
蛋白长度
Partial
-
分子量
45.8 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TMED9, a member of the transmembrane emp24 domain (TMED) protein family, has garnered significant interest in recent years due to its critical role in protein trafficking and secretion within the cell. This protein primarily functions in the endoplasmic reticulum (ER) and Golgi apparatus, mediating the transport of newly synthesized proteins to their final destinations. Dysregulation of TMED9 has been implicated in various diseases, including cancer and neurodegenerative disorders, highlighting its potential as a therapeutic target. Studies suggest that TMED9 interacts with various cargo proteins, influencing their maturation and export processes, which further underlines its importance in maintaining cellular homeostasis. Additionally, the use of recombinant TMED9 protein in biological assays has facilitated the exploration of its structural and functional properties, providing insights into its mechanisms of action. Understanding the intricate details of TMED9's function could lead to novel approaches in treating diseases where protein trafficking is disrupted, making it a focal point for ongoing research in cell biology and biomedicine.
