Analytical Data
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Gene name
GNGT1
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简介
GNGT1 protein, a member of the G protein family, is crucial in diverse transmembrane signaling systems, functioning as a modulator or transducer. Its beta and gamma chains facilitate GTPase activity, enabling GDP-GTP exchange and mediating interactions with effectors. G proteins, with three subunits—alpha, beta, and gamma—collaboratively regulate and transduce signals across cell membranes. GNGT1 Protein, Human (His) is the recombinant human-derived GNGT1 protein, expressed by E. coli , with N-His labeled tag.
- Application
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Alternative Names
Guanine nucleotide-binding protein G(T) subunit gamma-T1; Transducin gamma chain
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P63211
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Expression Region
P2-C71
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Protein Length
Full Length of Mature Protein
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Molecular Weight
9.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Kirrel1, also known as NEPH1, is a member of the nephrin-like proteins, which play a critical role in the development and maintenance of the glomerular filtration barrier in the kidney. This protein is primarily expressed in podocytes, specialized cells that line the outer layer of the kidney's glomeruli. Disruptions in Kirrel1 function have been implicated in various kidney diseases, including nephrotic syndrome and focal segmental glomerulosclerosis (FSGS). Research into the recombinant form of Kirrel1/NEPH1 has gained significance as it provides insights into its structural and functional properties, enhancing our understanding of podocyte biology and the mechanisms underlying kidney pathologies. The production of recombinant Kirrel1 allows for detailed biochemical analyses and the exploration of its interactions with other key proteins involved in cell adhesion and signaling pathways. Additionally, studying its role in proteinuria can facilitate the development of potential therapeutic strategies for kidney disorders. Understanding the molecular characteristics of Kirrel1/NEPH1 and its contributions to glomerular function is essential for advancing our knowledge of kidney health and disease management.
