Analytical Data
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基因名
EXOSC9
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简介
EXOSC9 is a noncatalytic RNA exosome complex component that critically drives 3'->5' exoribonuclease activity and contributes to a variety of cellular RNA processing and degradation events. In the nucleus, it helps stabilize the maturation of RNA species and eliminates processing by-products, non-coding transcripts and defective mRNAs, thereby inhibiting their cytoplasmic export. EXOSC9 Protein, Human (sf9, His) is the recombinant human-derived EXOSC9 protein, expressed by Sf9 insect cells , with N-His labeled tag.
- Application
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别名
Exosome complex component RRP45; Autoantigen PM/Scl 1; PM/Scl-75; PMSCL1
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种属
Human
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表达系统
Baculovirus
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q06265-1
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表达区间
M1-N439
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蛋白长度
Full Length of Isoform-1
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EXOSC9, a core component of the exosome complex, plays a vital role in RNA processing and degradation, influencing cellular RNA metabolism and gene regulation. As an essential protein involved in maintaining RNA homeostasis, its dysfunction has been implicated in a variety of diseases, particularly those affecting the nervous system, such as neurodegenerative disorders. The study of EXOSC9 recombinant protein is critical for understanding its structural and functional characteristics, as well as its interactions with other proteins and RNA substrates. Furthermore, elucidating the biochemical pathways in which EXOSC9 participates could provide insights into the molecular mechanisms underlying its role in disease pathogenesis. Recent advances in recombinant protein technology enable the expression and purification of EXOSC9, facilitating the investigation of its enzymatic activities and potential therapeutic applications. Researchers are particularly interested in delineating how mutations in the EXOSC9 gene contribute to disease phenotypes and exploring the potential of targeting the exosome complex in drug development. By leveraging tools such as crystallography and cryo-electron microscopy, studies aim to reveal the three-dimensional structure of EXOSC9 and its complexes, offering valuable information for the design of small molecules that could modulate its activity. Overall, the investigation of EXOSC9 recombinant protein is a promising area of research that bridges fundamental molecular biology and clinical relevance, thereby enhancing our understanding of cellular RNA regulation and its implications in health and disease.
