Cat: IPD-X36072

Recombinant Human IL-2R alpha/CD25 Protein (HEK293),His

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Analytical Data

  • 基因名

    IL-2R alpha/CD25

  • Application

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    CD25; IL2R-a; IL2-RA; IDDM10; IL2R; TCGFR; p55; TAC antigen

  • 种属

    Human

  • 表达系统

    HEK293

  • 标签

    N-His

  • 纯度

    Greater than 95% as determined by SDS-PAGE.

  • 蛋白编号

    P01589

  • 表达区间

    Glu22~Gln240

  • 分子量

    44kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

Interleukin-2 receptor alpha (IL-2Rα), also known as CD25, is a crucial component of the interleukin-2 (IL-2) signaling pathway, which plays a significant role in regulating immune responses and maintaining T cell homeostasis. The study of IL-2Rα/CD25 recombinant proteins has gained prominence due to their involvement in various autoimmune diseases, cancers, and immune system regulation. CD25 is expressed on activated T cells and is essential for T cell proliferation, differentiation, and survival. The overexpression of CD25 is often associated with pathological conditions such as lymphoproliferative disorders and some cancers, making it a potential therapeutic target. Moreover, CD25 is upregulated on regulatory T cells (Tregs), which are vital for maintaining immune tolerance and preventing autoimmunity. Recombinant forms of IL-2Rα/CD25 can be utilized for immunological studies, allowing researchers to investigate the interactions between IL-2 and its receptor, facilitate the development of targeted therapies, and enhance the understanding of immune modulation. These proteins also hold promise in the context of immunotherapies, where enhancing or inhibiting IL-2 signaling may lead to improved treatment outcomes in various diseases. Overall, the research on IL-2Rα/CD25 recombinant proteins is pivotal to advancing immunotherapy and enhancing our understanding of immune system dynamics.

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IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
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