Analytical Data
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Gene name
BVES
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简介
BVES protein is a cell adhesion molecule that is essential for the paracellular permeability barrier of tight junctions in epithelial cells. BVES Protein, Human (GST) is the recombinant human-derived BVES protein, expressed by E. coli , with N-GST labeled tag.
- Application
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Alternative Names
Blood vessel epicardial substance; hBVES; Popeye protein 1; BVES; POP1; POPDC1
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Species
Human
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Source
E. coli
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Tag
N-GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8NE79
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Expression Region
M1-N36
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Protein Length
Partial
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Molecular Weight
32.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of BVES (Blood Vessel Epicardial Substance) recombinant proteins has garnered significant attention due to their potential roles in cardiovascular health and development. BVES is a tight junction protein primarily expressed in endothelial cells, contributing to cellular adhesion and barrier function. Research indicates that BVES plays a pivotal role in maintaining vascular integrity and regulating angiogenesis, as well as influencing cellular signaling pathways associated with inflammation and repair mechanisms. Dysfunction or downregulation of BVES has been linked to various cardiovascular diseases, including hypertension and atherosclerosis. Furthermore, BVES expression has been shown to be modulated in response to stressors like hypoxia, suggesting its involvement in adaptive responses during disease progression. The production of recombinant BVES proteins allows for detailed investigations into their structural and functional properties, facilitating the exploration of their therapeutic potential. By understanding the molecular mechanisms underlying BVES function, researchers aim to develop innovative strategies for treating cardiovascular conditions, thereby enhancing patient outcomes and advancing the field of vascular biology. This research is essential not only for elucidating the fundamental biology of the cardiovascular system but also for identifying novel biomarkers and targets for pharmacological intervention.
