Analytical Data
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Gene name
IL-1RA/IL-1RN
- Application
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Alternative Names
IL-1RN, IRAP, IL1 inhibitor
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Species
Mouse
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Source
E. coli
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Tag
Tag Free
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
P25085
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Expression Region
27-178aa
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Molecular Weight
17.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interleukin-1 receptor antagonist (IL-1RA or IL-1RN) is a crucial member of the interleukin-1 (IL-1) cytokine family, which plays a significant role in the regulation of immune and inflammatory responses. IL-1 is involved in various physiological processes such as hematopoiesis, bone metabolism, and the response to infections. However, excessive IL-1 activity is linked to numerous inflammatory diseases, including rheumatoid arthritis, coronary artery disease, and metabolic syndromes. The human IL-1RA is a natural antagonist that competes with IL-1 for binding to its receptor, thereby inhibiting the pro-inflammatory effects of IL-1. Recombinant IL-1RA has been developed as a therapeutic agent, showing promise in managing conditions characterized by chronic inflammation. Research into IL-1RA has expanded to explore its potential in various clinical settings, and studies have demonstrated its capacity to modulate immune responses in autoimmune conditions and other inflammatory disorders. Additionally, the understanding of IL-1RA's mechanisms of action has opened avenues for novel therapeutic strategies aimed at enhancing its efficacy, improving delivery methods, and reducing potential side effects. As such, the development and characterization of recombinant IL-1RA proteins remain a key area of interest in biomedical research, with ongoing studies focused on optimizing their therapeutic applications and elucidating their roles in disease pathology.
