Analytical Data
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Gene name
APLP-1
- Application
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Alternative Names
rHuAmyloid-like Protein 1, His; APLP-1; Amyloid-like Protein 1
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Species
Human
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P51693
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Expression Region
G42-P212
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Protein Length
Partial
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Molecular Weight
18-20 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
APLP-1, or Amyloid Precursor-Like Protein 1, is a member of the amyloid precursor protein (APP) family, which has garnered significant attention due to its potential roles in neurobiology and pathology, particularly in relation to Alzheimer’s disease. The research focus on APLP-1 has intensified as it is believed to participate in several crucial biological processes, including neurodevelopment, synaptic function, and neuronal survival. Unlike its widely studied relative APP, which is implicated in amyloid plaque formation, APLP-1 is thought to have neuroprotective properties and may interact with cellular signaling pathways that promote cell survival and repair. Investigating APLP-1's structural characteristics, expression patterns, and functional roles in the brain is pivotal for understanding its contributions to neural health and disease. Furthermore, the study of APLP-1, especially in the context of its interaction with other proteins and its involvement in neurodegenerative processes, could illuminate new therapeutic targets and strategies for preventing or mitigating conditions like Alzheimer's disease. Efforts to produce recombinant APLP-1 proteins are essential for detailed biochemical analyses and functional studies, paving the way for enhanced comprehension of its mechanisms and impacts in neurological contexts. Overall, APLP-1 stands at the intersection of neurobiology and potential therapeutic avenues, making it a significant focus of current biomedical research.
