Analytical Data
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基因名
ANGPTL3/Angiopoietin-like 3
- Application
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别名
ANGPT5; ANG-5; Angiopoietin 5; Angiopoietin-related protein 3
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种属
Mouse
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9R182
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表达区间
Thr237~Thr455
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蛋白长度
Partial
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分子量
55kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ANGPTL3, or Angiopoietin-like 3, is a protein that plays a significant role in lipid metabolism and cardiovascular health. It is primarily produced by the liver and is implicated in regulating triglyceride levels in the bloodstream. Research has shown that ANGPTL3 functions as an inhibitor of lipoprotein lipase (LPL), an enzyme vital for the hydrolysis of triglycerides in lipoproteins, thereby influencing overall lipid profiles. Dysregulation of ANGPTL3 has been linked to various metabolic disorders, including dyslipidemia and atherosclerosis, making it a potential therapeutic target for cardiovascular disease. Recent studies have focused on the development of recombinant ANGPTL3 proteins to investigate their structural properties and functional roles in lipid metabolism. These recombinant proteins are essential for elucidating the mechanisms by which ANGPTL3 affects triglyceride levels and for screening potential pharmacological agents that can modulate its activity. Understanding the function of ANGPTL3 and its influence on lipid metabolism could lead to innovative treatments for diseases associated with lipid dysregulation, positioning it as a promising area of research in metabolic health and cardiovascular risk management.
