Analytical Data
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基因名
RBBP4
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简介
The RBBP4 protein is a core histone-binding subunit that directs chromatin regulators and histone deacetylases to their substrates and participates in chromatin metabolism.RBBP4 Protein, Mouse (sf9, His) is the recombinant mouse-derived RBBP4 protein, expressed by Sf9 insect cells , with N-His labeled tag.
- Application
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别名
Histone-binding protein RBBP4; CAF-I p48; RBBP-4; RBAP48
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种属
Mouse
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表达系统
Baculovirus
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q60972
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表达区间
M1-S425
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蛋白长度
Full Length
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RBBP4, or Retinoblastoma Binding Protein 4, is a nuclear protein that plays a crucial role in various cellular processes, including cell cycle regulation, chromatin remodeling, and gene expression. It is known to interact with the retinoblastoma tumor suppressor protein, modulating its function and contributing to cell proliferation and differentiation. Research on RBBP4 has gained considerable attention due to its implications in cancer biology, particularly its involvement in tumor progression and the regulation of oncogenes and tumor suppressor genes. The reconstitution and characterization of RBBP4 recombinant protein are essential for understanding its structural and functional properties, which could reveal insights into the molecular mechanisms underlying cell cycle dysregulation in cancer. Additionally, studying the interactions of RBBP4 with other proteins and chromatin components can provide a better understanding of its role in epigenetic regulation. This research may also contribute to the development of targeted therapies for cancers associated with aberrant RBBP4 expression or function. Given the increasing evidence linking RBBP4 to various diseases, including several types of cancer, further investigation into its recombinant form is vital for elucidating its biological activities and potential as a therapeutic target.
