Analytical Data
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基因名
Histone H2B 1.1
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简介
Histone H2B 1.1 protein is a key nucleosome component that compacts DNA into chromatin, thereby restricting access to cellular processes. Histone H2B 1.1 Protein, Xenopus laevis is the recombinant Xenopus laevis-derived Histone H2B 1.1 protein, expressed by E. coli , with tag free.
- Application
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别名
H2B1.1
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种属
Xenopus laevis
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P02281
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表达区间
A2-K123
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蛋白长度
Full Length of Mature Protein
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分子量
13.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Histone H2B 1.1, a core component of the nucleosome, plays a crucial role in the structural organization of chromatin and the regulation of gene expression. As one of the five main histone proteins, H2B is involved in forming the octameric core around which DNA wraps, thereby influencing the accessibility of the DNA for transcriptional machinery. Research into H2B has gained momentum due to its implications in epigenetic regulation, particularly through post-translational modifications such as ubiquitination and methylation. These modifications can affect chromatin dynamics and gene activity, making H2B a focal point in studies related to cancer, developmental biology, and inheritance of epigenetic traits. Furthermore, the recombinant expression of Histone H2B 1.1 allows for the detailed investigation of its functional properties and interactions within the chromatin context. By utilizing techniques such as X-ray crystallography and cryo-electron microscopy, scientists aim to elucidate the structural basis of H2B's role in chromatin remodeling and its impact on various cellular processes. Understanding the functions and mechanisms associated with H2B 1.1 not only advances our fundamental knowledge of chromatin biology but also opens avenues for therapeutic developments targeting diseases linked to histone dysregulation.
