Analytical Data
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Gene name
B2M/Beta-2
- Application
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Alternative Names
BMG; B2MG
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Species
Mouse
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Source
E. coli
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Tag
N-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
P01887
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Expression Region
Gln22~Met119
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Molecular Weight
14kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
B2M, or Beta-2-microglobulin, is a small protein that plays a crucial role in the immune system, particularly in the presentation of peptide antigens to T cells as part of the major histocompatibility complex (MHC) class I molecules. Research into B2M has gained importance due to its implications in various diseases, including cancer, autoimmune disorders, and chronic kidney disease. Elevated levels of B2M have been associated with poor prognosis in multiple myeloma and other hematological malignancies, making it a potential biomarker for disease progression and therapeutic response. Furthermore, the reconstitution of B2M has been investigated for its potential benefits in improving immune responses, particularly in vaccine development and immunotherapy strategies. The ability to produce recombinant B2M allows for detailed studies on its structure-function relationship and the development of therapies that leverage its immunological properties. Overall, the ongoing research into B2M and its recombinant forms continues to provide valuable insights into both basic immunology and translational applications in clinical settings.
