Analytical Data
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基因名
AQP1
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简介
The AQP1 protein forms water-specific channels that allow water to cross red blood cells and renal proximal tubule membranes. AQP1 Protein, Human (His-SUMO) is the recombinant human-derived AQP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
- Application
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种属
Human
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表达系统
E. coli
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标签
N-6*His;N-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P29972
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表达区间
G220-K269
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蛋白长度
Partial
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Aquaporin 1 (AQP1) is a water channel protein that facilitates the transport of water across cell membranes, playing a crucial role in cellular osmoregulation and fluid homeostasis. The study of AQP1 has garnered significant interest due to its involvement in various physiological processes, including kidney function, eye health, and brain hydration. Additionally, dysregulation of AQP1 has been linked to several pathophysiological conditions, such as edema, diabetes insipidus, and cancer progression. The recombinant production of AQP1 provides a valuable tool for researchers to explore its structure-function relationship, investigate its role in cellular mechanisms, and develop potential therapeutic applications. Advances in protein expression techniques, particularly in systems like bacteria, yeast, or mammalian cells, have enabled the generation of high yields of functional AQP1. Characterization of the recombinant protein through techniques such as X-ray crystallography and cryo-electron microscopy has further elucidated its structural properties and permeability characteristics. By analyzing AQP1 interactions with various ligands and other proteins, researchers aim to deepen the understanding of its regulatory mechanisms and potential as a drug target. Overall, the study of recombinant AQP1 not only enhances insights into fundamental biological processes but also holds promise for innovative approaches to treat diseases associated with water transport dysregulation.
