Analytical Data
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Gene name
S100A7A
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简介
The S100A7A protein plays potential roles in skin homeostasis, epidermal differentiation, and inflammation, suggesting its importance in skin health and disease. Its involvement in cellular functions makes it a key factor in diseases such as psoriasis, which is characterized by abnormal epidermal processes and inflammation. S100A7A Protein, Human (P.pastoris, His) is the recombinant human-derived S100A7A protein, expressed by P. pastoris , with N-His labeled tag.
- Application
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Alternative Names
S100A7A; S100A15; S100A7L1; S100 calcium-binding protein A7A
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Species
Human
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Source
P. pastoris
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86SG5
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Expression Region
S2-Q101
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
S100A7A, also known as psoriasin, is a small calcium-binding protein belonging to the S100 family, which plays a significant role in various cellular processes, including inflammation, cell proliferation, and differentiation. It is primarily expressed in epithelial tissues and is highly upregulated in psoriatic skin, serving as a potent marker for psoriasis. Recent studies have highlighted its involvement in immune responses and its potential role in cancer progression, particularly in promoting tumorigenesis and metastasis in certain cancers. The interest in S100A7A as a research target has grown due to its dual function; while it mediates host defense mechanisms, it also appears to facilitate pathological processes in chronic inflammatory diseases and malignancies. To further understand its biological functions and therapeutic potentials, the recombinant protein S100A7A has been developed, enabling detailed studies on its structure, interaction with ligands, and effects on cell signaling pathways. This could provide insights into its mechanism of action and potential as a biomarker or therapeutic target in diseases like psoriasis and cancer. As research progresses, the recombinant S100A7A protein may pave the way for the development of new treatment strategies aimed at modulating its activity for beneficial outcomes in inflammatory disorders and tumor biology.
