Analytical Data
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Gene name
Lymphocyte antigen 6E/LY6E
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简介
LY6E is a GPI-anchored cell surface protein that regulates T lymphocyte function by binding to CD3Z/CD247, affecting proliferation, differentiation and activation.It modulates T cell receptor signaling and exhibits antiviral activity against mouse hepatitis virus.Lymphocyte antigen 6E/LY6E Protein, Mouse (P.pastoris, His, SUMO) is the recombinant mouse-derived Lymphocyte antigen 6E/LY6E protein, expressed by P.pastoris , with N-His, N-SUMO labeled tag.
- Application
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Alternative Names
Ly6e; Ly67; Sca-2; Tsa-1Lymphocyte antigen 6E; Ly-6E; Stem cell antigen 2; Thymic shared antigen 1; TSA-1
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Species
Mouse
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Source
P. pastoris
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Tag
N-His;N-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q64253
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Expression Region
L21-A102
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Lymphocyte antigen 6E (LY6E) is a member of the LY6 family, which encompasses a variety of cell surface glycoproteins known to be involved in immune responses. Recent studies have highlighted the critical roles of LY6E in modulating T-cell activation and influencing cytokine production. Additionally, LY6E has been implicated in viral infections, particularly with its role in the entry and replication of several pathogens. Understanding the structure and function of LY6E is vital for elucidating its mechanism in immune regulation and potential therapeutic applications. The study of recombinant LY6E protein focuses on its expression, purification, and functional characterization, aiming to explore its interactions with immune cells and elucidate its biological activities. This research is paramount for developing strategies to enhance immune responses, combat viral infections, and generate immunotherapeutic agents. Advances in recombinant protein technology have facilitated the production of LY6E, allowing for detailed analyses of its functions both in vitro and in vivo. By investigating LY6E through recombinant protein models, scientists can potentially identify novel pathways for intervention in immune-related disorders and improve our understanding of host-pathogen interactions. The comprehensive study of LY6E is therefore not only crucial for fundamental immunology but also for its translational implications in vaccine development and immunotherapy.
