Analytical Data
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基因名
OSMR
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简介
The OSMR beta Protein, in partnership with IL31RA, constitutes the IL31 receptor, binding IL31 to activate STAT3, and potentially STAT1 and STAT5.OSMR beta also transduces OSM-specific signaling.It forms a heterodimer with IL6ST, creating the type II OSM receptor, and another heterodimer with IL31RA for the IL31 receptor.OSMR beta Protein, Mouse (HEK293, His) is the recombinant mouse-derived OSMR beta protein, expressed by HEK293 , with C-His labeled tag.
- Application
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生物活性
Measured by its binding ability in a functional ELISA. When Recombinant Mouse OSM R beta is immobilized at 0.5 µg/mL and Recombinant Mouse gp130 at 0.5 µg/mL (100 µL/well) can bind Recombinant Mouse OSM. The ED50 for this effect is 0.9183 ng/mL. Measured by its binding ability in a functional ELISA. When Recombinant Mouse OSM R beta is immobilized at 0.5 µg/mL and Recombinant Mouse gp130 at 0.5 µg/mL (100 µL/well) can bind Recombinant Mouse OSM. The ED50 for this effect is 0.9183 ng/mL.
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别名
IL-31R subunit beta; IL-31R-beta; IL-31RB; OSMR beta; OSMR; OSMRB; OSMRBMGC150626; PLCA1 ; IL-31R subunit β; IL-31R-β; OSMR β
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种属
Mouse
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表达系统
HEK293
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标签
C-8*His;C-His
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纯度
> 90% as determined by SDS-PAGE.
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蛋白编号
O70458
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表达区间
E24-M737
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蛋白长度
Partial
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分子量
115-140 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
OSMR (Oncostatin M receptor) is a member of the interleukin-6 receptor family, playing a crucial role in various physiological processes, including inflammation, hematopoiesis, and development. Research into OSMR has gained momentum due to its involvement in several pathological conditions, such as cancer, autoimmune diseases, and infections. The receptor mediates the effects of oncostatin M, a cytokine that influences cell proliferation, differentiation, and survival. Moreover, OSMR's signaling pathways, particularly those involving Janus kinases (JAKs) and signal transducers and activators of transcription (STATs), are central to understanding the receptor's function in both normal and disease states. Recent studies have highlighted the potential for OSMR as a therapeutic target, as its modulation could provide novel approaches for treating diseases characterized by dysregulated inflammatory responses. Therefore, the development of recombinant OSMR proteins is essential for further elucidating its biological functions, exploring its role in cellular signaling, and assessing its therapeutic potential. The ongoing research into OSMR and its recombinant forms not only aims to expand our understanding of immune regulation and cellular communication but also seeks to pave the way for innovative treatments that harness the biology of this receptor in disease management.
