Analytical Data
-
Gene name
SOCS1
- Application
-
Alternative Names
JAK-binding protein
-
Species
Mouse
-
Source
E. coli
-
Tag
N- His & C- Myc
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
O35716
-
Expression Region
1-212aa
-
Molecular Weight
28.7 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SOCS1 (Suppressor of Cytokine Signaling 1) is a critical regulator of cytokine signaling pathways, primarily involved in modulating immune responses and inflammation. It is a member of the SOCS family, which plays a crucial role in the negative feedback regulation of various cytokines, especially those of the IL-6 family and the JAK-STAT signaling pathway. Dysregulation of SOCS1 has been implicated in a variety of pathological conditions, including autoimmune diseases, chronic inflammation, and cancer. Recent studies have highlighted the role of SOCS1 as a tumor suppressor, suggesting that its loss or mutation may contribute to tumorigenesis. Additionally, SOCS1 has been shown to influence various cellular processes, such as cell proliferation, apoptosis, and differentiation. Given its important functions, researchers are increasingly focused on understanding the molecular mechanisms underlying SOCS1's action and exploring its potential as a therapeutic target. This includes the study of SOCS1 recombinant proteins to elucidate their structural and functional properties, which could pave the way for developing novel interventions in diseases characterized by aberrant cytokine signaling. Understanding SOCS1's role at the molecular level may also provide insights into more effective treatment strategies for immune-related disorders and cancers, highlighting its significance in both basic research and clinical applications.
